To analyze microsatellite instability ( MSI) and loss of heterozygosity ( LOH) at 8 loci of different chromosomes from 17 chronic leukemic patients and 11 health volunteers with polymerase chain reaction ( PCR) technology. 应用PCR扩增技术检测17例慢性白血病患者不同染色体上8个微卫星位点的微卫星不稳定性(MSI)和杂合性缺失(LOH),同时检测11例健康志愿者的MSI和LOH,以作对照。
Conclusion Besides inducing apoptosis and restraining proliferation of leukemic cells, ATRA and DNR exerted their anti-leukemia effects by reducing angiogenesis via reduction of angiogenic reaction stimulating signals. 结论这两种化疗药物除了可以诱导白血病细胞分化或抑制白血病细胞生长外,还可以通过抑制促血管新生,使新生血管减少,以发挥抗白血病的效应。